Co-Codamol 30-500mg Zapain Tablets
Co-Codamol 30-500mg Zapain Tablets are a prescription painkiller containing two active ingredients: 30mg codeine phosphate and 500mg paracetamol per tablet. Codeine is an opioid analgesic, while paracetamol provides additional pain-relieving and fever-reducing effects.
Zapain is used for the relief of severe pain and can also be prescribed for short-term acute moderate pain in people over 12 when other painkillers, such as paracetamol or ibuprofen alone, have not provided adequate relief.
Because Zapain contains codeine, prolonged or repeated use can lead to tolerance, physical dependence and addiction. It should be used only by the person for whom it has been prescribed and according to professional medical advice.
What Is Co-Codamol 30-500mg Zapain?
Co-Codamol 30mg/500mg, marketed as Zapain 30mg/500mg Tablets, is a combination medicine containing:
- Codeine phosphate 30mg
- Paracetamol 500mg
The two ingredients provide pain relief through different mechanisms. Codeine acts on opioid receptors and affects how the central nervous system processes pain, while paracetamol provides additional analgesic activity.
What Is Zapain 30mg/500mg Used For?
Zapain may be prescribed for:
- Relief of severe pain
- Short-term treatment of acute moderate pain in appropriate patients over 12 years of age
- Pain that has not been adequately controlled by paracetamol or ibuprofen alone
The medicine should be used at the lowest effective dose for the shortest appropriate period. UK product information recommends limiting treatment for pain to three days unless further medical advice is obtained.
How Does Zapain Work?
Zapain combines an opioid analgesic with paracetamol.
Codeine phosphate acts within the central nervous system and is partly converted to morphine in the body, contributing to its analgesic effect. Paracetamol provides additional pain-relieving activity.
Individual responses to codeine can vary, so treatment should always follow the instructions provided by the prescriber.
Zapain 30mg/500mg Side Effects
Possible side effects include:
- Drowsiness or sleepiness
- Dizziness
- Nausea or vomiting
- Constipation
- Dry mouth
- Sweating
- Confusion
- Reduced alertness
- Blurred or double vision
Codeine can also cause dependence and withdrawal symptoms following regular use.
Serious Side Effects
Seek urgent medical attention if you experience severe breathing difficulties, extreme drowsiness, loss of consciousness or symptoms of a serious allergic reaction.
An overdose is particularly important because Zapain contains paracetamol. Taking too much paracetamol can cause serious liver damage, even when a person initially feels well.
Zapain Precautions
Before taking Zapain, tell your doctor or pharmacist if you:
- Have breathing or lung problems
- Have liver or kidney problems
- Have a history of dependence or addiction
- Are elderly or particularly frail
- Have recently suffered a head injury
- Take medicines that cause drowsiness
- Take other opioid painkillers
- Regularly consume alcohol
Zapain should not be combined with other medicines containing paracetamol unless specifically instructed by a healthcare professional.
Zapain and Dependence
Zapain contains codeine, an opioid that can cause tolerance, dependence and addiction.
Regular use can result in withdrawal symptoms if treatment is stopped suddenly. Your prescriber should advise you about the appropriate duration of treatment and how to stop safely when necessary.
How Should Zapain 30mg/500mg Be Taken?
Take Zapain exactly as prescribed by your doctor or pharmacist.
The UK product information gives adult dosing of one or two tablets when required at the specified intervals, with a maximum of eight tablets in 24 hours. However, patients should follow their individual prescription and the leaflet supplied with their medicine rather than changing the dose themselves.
Zapain should not be taken for longer than directed. For pain, the product information recommends seeking medical advice if effective relief has not been achieved after three days.
Zapain Interactions
Zapain can interact with other medicines, particularly medicines that cause sedation or affect breathing.
Tell your doctor or pharmacist if you take:
- Other opioid painkillers
- Benzodiazepines or other sedatives
- Sleeping medicines
- Certain antidepressants
- Medicines that cause drowsiness
- Anticoagulants such as warfarin
- Other medicines containing paracetamol or codeine
Combining opioids with sedative medicines can increase the risk of severe drowsiness, respiratory depression, coma and other serious effects.
Frequently Asked Questions
What is Co-Codamol 30-500mg Zapain?
Zapain is a combination painkiller containing 30mg codeine phosphate and 500mg paracetamol per tablet.
What is Zapain 30mg/500mg used for?
It is prescribed for severe pain and, in appropriate patients over 12, short-term acute moderate pain that has not been adequately relieved by other analgesics.
Is Zapain an opioid?
Yes. Zapain contains codeine, which is an opioid analgesic.
Can Zapain cause addiction?
Yes. Codeine can cause tolerance, dependence and addiction, particularly with repeated or prolonged use.
Can I take paracetamol with Zapain?
Zapain already contains 500mg of paracetamol per tablet. You should not take other paracetamol-containing medicines while using Zapain unless specifically advised by your healthcare professional.
Can Zapain make me sleepy?
Yes. Drowsiness and reduced alertness can occur. Do not drive or operate machinery if you are affected.
What happens if I take too much Zapain?
An overdose can cause serious toxicity, including potentially life-threatening effects from both codeine and paracetamol. Seek urgent medical attention if you take more than prescribed.
Cura Point Pharmacy
Cura Point Pharmacy provides clear and responsible information about prescription medicines and their appropriate use. Co-Codamol 30-500mg Zapain should only be used by the person for whom it has been prescribed and according to the instructions of a qualified healthcare professional.






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